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A team of doctors in the Johns Hopkins University is making waves among the medical fraternity, after they have come out successfully from a research, which proves that a PDE5 inhibitor like Viagra can treat and prevent recurring priapism in men.
Priapism is a disturbing and discomforting disorder among men, as men suffer from fatal, recurring erections that can have a debilitating effect on his normal erectile functions, during each spell of priapism. Generally, men go through two types of priapism – ischemic or non-ischemic. The first case of priapism occurs due to idiopathic reasons, or reasons related to drug use, while the non-ischemic priapism is usually caused by traumas and other psychological factors. Priapism can occur either as an isolated episode, or occur recurrently at frequent intervals, almost everyday.
Previous researches have aptly demonstrated and established that a dysregulated phosphodiesterase-5 (PDE5) plays an important role in the pathogenesis of priapism, giving a clear indication that PDE5 may serve as a molecular target for the treatment or prevention of the disorder. Dr. Burnett and his colleagues in Johns Hopkins University, Baltimore, USA focused on this hypothesis to carry out the path breaking research.
The research team administered a long term PDE5 inhibitor treatment to three men with priapism due to sickle cell disease and a man with complaint of recurrent idiopathic priapism. They were given 25 to 30 mg oral dosage of Sildenafil (Viagra) in the morning three times a week, for a long period of time.
The patients were closely followed and examined for a period of three to eleven months, and it was found that the rate of occurrence of priapism gradually came down to very rare or occasional. The research team said that the encouraging results prove the dysregulated PDE5 hypothesis. It shows that this treatment resets the erectile regulatory function of PDE5 back to normal and protects the penis from episodes of priapism.
The revolutionary research defies conventional wisdom and judgment that Viagra and its class of drugs are contraindicated in patients with priapism. It would indeed be tough for a layman to fathom the fact that an erection enhancing medication like Viagra is used in the prevention of an uncontrollable and never waning erection. The highly complicated research based on cellular regulatory model may baffle you, as it challenges your traditional logic, but never forget that every discovery has been received in the same light.
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If you have a watery, painful blister on your skin, mouth, lips or genitals, it may be time to pay your doctor a visit. It may be just a minor infection, but it could also be a dreaded cold sore, more popularly known by the term herpes simplex virus or HSV.
HSV is very contagious, especially when it has just been contracted and the first symptoms are only beginning to make themselves known. The most distressing thing about this horrible health disorder is that there is no cure. If you get cold sores, you will be carrying them around the rest of your life like luggage.
Cold sores come by many names, including Night Fever and Fever Blister. They are sometimes mistaken for canker sores (Apthous ulcers) because they have the same appearance and show themselves frequently on the inside of the mouth. The difference is that canker sores are not caused by the herpes simplex. If your doctor told you that you have canker sores instead of cold sores, you should thank your lucky stars.
There are many other symptoms of HSV aside from cold sores. These include skin irritations, clusters of blisters in different parts of your body and lesions that leave no scars when they heal.
The cold sore lesions often appear around the genital area in men and also around the buttocks or anus, inner thigh or on the shaft of the penis. In women, the lesions can usually be found on or near the pubis, vulva, labia, clitoris, anus or buttocks. Sometimes, they are not obvious to the eye and at other times, you can’t miss them when they’re there.
Cold sores look different from individual to individual. Often, they appear to be blisters, especially in the genital area, but they also sometimes appear to be a yeast infection or a bad case of chafing.
Aside form the signs that you see around your body, cold sores are also characterized by a general ache all over your body and a bit of pain in the genital area, discomfort or pain during urination and discharges from the penis or vagina. There may also be flu-like symptoms that last for a week. Outbreaks usually come four or five times a year.
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Carl Anderson: singer and known for his portrayal of Judas Iscariot in the phenomenal hit "Jesus Christ Superstar," died February 13, 2004.
Susan Sontag: writer, intellectual, activist, National Book Award recipient, died December 28, 2004.
Bruno Kirby: actor, Pete Clemenza of "The Godfather Part II," died August 14, 2006.
Leukemia knows no profession, age, gender, race, or economic status. It can inflict anyone, anytime, anywhere. About 31,000 each year, 2,566 every month, 592 each week, 84 a day, 3 each hour are the numbers to speak for leukemia's prevalence -- at least, in America.
Leukemia is among the many deadly cancer types. Leukemia is a cancer that affects the blood or the marrow of the bone. This cancer type is characterized by the overproduction of certain blood cells, most common of which is the white blood cells or leukocytes. When there is an overproduction of white blood cells in the bone marrow, the regular amount of red blood cells, white blood cells, and platelets are being outnumbered and the blood gets a hard time to do its normal functions.
A leukemia case may be classified as either in the chronic stage or acute stage. Chronic leukemia is the stage when the unnecessary blood cells are still able to perform their normal function. Chronic leukemia commonly occurs among older people. Since leukemia at this stage does not show any sign or symptom, it is often undetected and eventually gets worse and reach the acute stage. A leukemia that reached the acute stage is already a harmful case. Here, the production is really way above the normal rate and the unnecessary blood cells do not perform their normal functions anymore. Acute leukemia is very common among children. It is actually known as among the leading causes of death among American children.
Leukemia has four known types: the chronic lymphocytic leukemia, acute lymphocytic leukemia, chronic myeloid leukemia, and acute myeloid leukemia. A leukemia is lymphocitic, if the lymphoid cells and myeloid cells are affected. Chronic lymphocytic leukemia is most common among adults above 55 years of age. This kind is almost non-existent among children, and accounts for about 7,000 cases each year. Acute lymphocytic leukemia, on the contrary, is most common among children and very rare among adults. The number of new acute lymphocytic leukemia cases total to about 3,800 every year. The estimate of chronic myeloid leukemia is at 4,400 new cases annually and is mainly affecting adults; on the other hand, acute myeloid leukemia is at a higher number at 10,600 count each year.
As with other cancer types, the causes of leukemia is still unknown. The closest the medical field has gone in determining the root cause of leukemia is the identification of risk factors or the things that increase the probability of one developing the disease. First and common to all cancer types is genetic influence. People with relatives who had any cancer type, died or survived, are at a very high risk level of having leukemia. Environmental factors, such as high radiation exposure and contact with carcinogenic materials, are also high risk factors. Exposure to chemicals and substance, such as benzene and formaldehyde, in the workplace or in other places also increases the risk of having leukemia. Medical conditions such as chemotherapy from a previous cancer, Down syndrome, and myelodysplastic syndrome are also known risk factors.
The most common symptoms of leukemia are flu-like ailments like fever and chills, bleeding and swollen gums, enlargement of spleen and liver, fatigue and frequent weakness, anemia, loss of weight, poor appetite, swollen lymph nodes, pain in joints and/or bones, and abdominal pains. However, these signs are not exclusive to leukemia alone. The safest way to confirm a possible leukemia case is through medical tests.
The treatment for leukemia is dependent on each particular case. But the most common treatment options are chemotherapy, radiation therapy, bone marrow transplantation, biological therapy, or surgery for cases with enlarged spleen. As may be required in special cases, a combination of the possible treatments can be administered. Patients suffering from acute leukemia need to be treated right away to mitigate the spread of cancer cells and the damages they may cause. Patients suffering from chronic leukemia, on the other hand, may not be in urgent need of a treatment, especially if there are no symptoms persisting. After any treatment, patients are highly encouraged to undergo post-traumatic care or supportive care for emotional and psychological conditioning.
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We adopted our first child when he was three months old. When we went to the agency to get him, he promptly stood up on my wife's lap and looked out the window. He was robust and happy, sleeping through the night from the beginning. In fact he was such an easy baby that we really wondered why parenting was considered to be such an ordeal. We found out later. In fact he was such an ideal baby that we assumed all were the same. Not so. Our second had colic and didn't sleep through the night for nearly two years.
As Clint got older we saw that he was extremely bright. At nine months he spoke his first sentence. Our cat crawled past him on a sofa, then jumped off and disappeared. Clint said, "Where did it go, the Wow?" A Germanic construction, for sure, but easily understandable. His verbal precocity stayed with him throughout his childhood. At age eight he called the local pizzeria to order a pizza (without our knowledge of course. When he finished, the clerk said, "Thanks for your order, Ma'am." We had to talk to the pizxeria to make sure he didn't make any more such orders. He was very gregarious and adults loved being able to carry on intelligent conversations with him.
He never was at a loss for words. When he was about three the mother of a friend of his had another baby. He came home excitedly to tell the news. When we asked whether it was a boy or a girl, he frowned, obviously not sure. Then he brightened and said, "It came out of Linda's 'gina, but it had Mark's penis." OK, enough information; it's a boy.
When he was five, a neighborhood grandpa-type died. He had been a heavy smoker and had told the neighbor kids that he was sick because of smoking and didn't want them ever to do it. (It was a great gift, as none of the kids, now in their thirties, ever smoked). Emmett died of lung cancer and my wife took Clint to the reviewal before the funeral. It was his first such experience. They were alone for a while, so she lifted Clint so he could see Emmett in the open casket. The questions were non-stop. "Why does he have a flag?" She explained that he was a veteran. "Why does he have a bracelet on?" She explained it was a rosary, or prayer beads. "Why does he have his glasses on. He can't see, can he?" My wife kept a straight face and explained that Emmett's family wanted him to look the way they remembered him. Clint asked, "Why didn't they put a cigarette in his mouth, then?"
He also showed great mechanical and problem-solving ability. Once he was with me when I tried to open the shed to get out the lawn mower. The lock was rusty and wouldn't open. "Why don't you use a rusty key?" Clint asked helpfully.
As he approached adolescence, the phrase "too smart for his own good" fit him to a tee. Bored in school. Clint began finding friends who shared his strong interest in cars. Some of them were into stealing car parts or "borrowing" cars for joy rides. He was usually the planner and the lookout rather than the perpetrator, but that didn't keep him from troubles with the law that he couldn't talk his way out of. We had several dismal years of bailing him out of jail, court appearances and stays in correction facilities.
We all survived through some very trying times. If there's a solution in dealing with a too-bright kid, it's listening. Try to figure out what he's thinking so you have a chance to avert plans that you know will end in trouble. Let him know you're proud of him but will keep a watchful eye. Remind him that you sometimes need him to slow down and explain things, and think them through.
Most of all, do the toughest thing of all and set limits. They'll hate you for it at the time, but in the end they'll thank you.
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There are three stages of pregnancy. These are the first, second and third trimesters. The first trimester runs from week one to week fourteen, the second covers weeks 15 – 26, then the third is weeks 27 – 40.
Week 1+2: This is actually before you get pregnant. It’s the stage where your body prepares itself by ovulating. And it’s in these 14 days that the egg is fertilized by the sperm
Week 3: The fertilized egg now moves down the fallopian tubes, fluid passes into the ball of cells, dividing them into two. The inner cells will form your baby and the outer cells will form the placenta. Your body, at this stage, is still unaware that it is pregnant. The implantation begins as the cell ball reaches the wall of the uterus. In this process the cells actually bury into the uterus wall, which can sometimes lead to you having spotting. The implanted cell ball now becomes an embryo.
Week 4: This is a week of rapid development, and your body now realises it is pregnant. The amniotic sac and cavity begin to develop and also the Yoke sac appears (this will later form the baby’s digestive system). The placenta now starts to form where implantation took place and blood from you will now go into the placenta. It is usually about day 27 that we start to feel the morning sickness.
Week 5: The primitive streak (the fore runner of the brain and spinal cord) is now developing. Through this primitive streak the cells will develop into three layers:
The endoderm: the bottom layer – develops the glands, lung linings, tongue, bladder, digestive tract, tonsils, urethra and associated glands.
The mesoderm: the middle layer – forms the muscles, bones, heart, lungs, spleen, blood cells, and the reproductive and excretory systems.
The ectoderm: the top layer – forming the skin, nails, hair, eye lens, nose, mouth, anus, tooth enamel, pituitary gland, mammary glands, and all parts of the nervous system.
Other cells will be starting to develop the spine (called the notochord). The first steps towards forming the embryos head, and the first formation of the babies blood cells happen this week.
Week 6: The first few days of this week is when your baby’s heart starts beating. The aorta (the largest artery in the whole body) will be starting to form at around day 40. By mid week many organs are starting to form: eyes, arm buds, liver, gall bladder, stomach and intestines, lungs and pancreas.
Week 7: This is a busy week for your growing baby. During this week your baby will double in size. The lenses of the eyes are developing and there is also a recognisable tongue. The legs and arms are developing into paddles, the jaws are now visible.
Week 8: The cerebellum starts to form this week. That’s the part of the brain responsible for the movement of muscles. Also hand and foot plates, elbow and wrist areas are forming. Towards the end of the eight week the hand plate has formed ridges where the fingers will be. There is further development of the eye; pigment is now appearing on the retina. Teeth buds are now forming within the gums, along with the wind pipe, bronchi, and voice box. The heart is now starting to develop the four chambers.
Week 9: Your baby is now starting to form cartilage and bones. During this week the ovaries will develop into the sex organ determining whether you’re having a boy or a girl. The fingers and thumbs are now taking shape. Also the baby is now becoming more active.
Week 10: It’s now that your embryo has become a baby, all be it on a rather small scale. There is a fully formed upper lip. The development of the heart now slows as it is past the critical stage. By mid week the earlobes are fully formed. Toes start to develop on the foot plate. As the bones of the palate (roof of the mouth) start to fuse together, the tongue starts to develop taste buds.
Week 11: as the morning sickness starts to subside, you may feel your appetite increase. Your baby’s body starts to straighten. In males the penis is now distinguishable and in females the vagina is beginning to develop. This stage is where the baby starts to show individuality, as the muscle structure varies in each baby.
Week 12: Your baby will start to develop fingernails over the next three weeks. The brain is now the same structure as it will be at birth. By the end of the week, the gall bladder and pancreas will be fully developed. Also the baby will now be opening and closing its mouth.
Week 13: This week vocal chords will form in the larynx. Also the intestines will move from the umbilical cord into the abdomen, and will start to form folds and become lined with villi.
Week 14: You may have noticed some changes to the areola (the area around your nipple); it may be getting larger and darker. Your baby’s heart beat will now be able to be heard using a Doppler. Breathing, sucking and swallowing motions will be being practised. The breathing practises will take the amniotic fluid in and out of the lungs. Baby’s hand also becomes more functional.
Week 15: The baby’s neck is now defined, with the head now resting on the neck rather than the shoulders. The hair pattern of the baby will be defined by the 102nd day of the pregnancy your baby will now be able to turn its head, open its mouth, kick, press its lips together and turn its feet.
Week 16: This week the baby’s toe nails will start to grow. The muscles will be growing stronger and the neck and head are growing straighter. As the uterus starts moving upwards you may start showing more, but this does mean less pressure on your bladder, making you feel like urinating less.
Week 17: Your baby will be working on more reflexes this week; blinking, sucking, and swallowing. Development is carrying on with all the existing structures. Through the course of this month your baby’s weight will increase 6 times.
Week 18: By mid week your baby’s eyes and ears will now be in the right places. The finger tips and toes will develop pads, and toe and finger prints will start to develop later in the week. Myelinization, a process of coating the nerves with a fatty substance called myelin which speeds up nerve cell transmission and insulates nerves, will start happening this week. Also by the second day of this week meconium (faecal waste) will start developing in the baby’s bowels.
Week 19: A creamy looking substance that covers the baby’s body, vernix coseosa, will start to form. This protects the baby and its developing glands and sensory cells. If you’re having a baby girl primitive egg cells are now developed in the ovaries, in fact females are born with all the eggs their ovaries will ever have.
Week 20: Most of the major development has now taken place, and the danger zone of the first three months is now over. Your baby will be waking and sleeping, just as newborns do. Also the formation of fine scalp hair and eyebrows will begin.
Week 21: Your body is replacing the amniotic fluid very three hours at this stage of your pregnancy. Baby’s leg and arm movements increase as the muscles and bones become stronger. By the end of the week a stethoscope will be able to detect the baby’s heart beat.
Week 22: If the baby is a boy, the testes will start to move from the pelvic area into the scrotum. The hair on the head and eyebrows is now visible as white and short.
Week 23: The bones in the middle ear start hardening making the conduction of sound possible. The baby will start to gain some considerable weight between now and next month. The size of the baby’s body will start to get into proportion though the head will remain larger than the rest of the body.
Week 24: The skin of your baby is wrinkled, but will smooth out as fat is deposited. Also by the end of this week the baby’s heart beat is so strong it is some times possible to hear it by placing an ear on your stomach.
Week 25: Baby’s skin is now turning a reddish/pink as capillaries start to develop. The nostrils will now start to open, as they have been plugged unto now. The lungs will start developing blood vessels and the finger and toe nails will now be covering half the nail bed.
Week 26: with the nostrils now open, muscular breathing will start. By the end of the week the lungs will be secreting surfactant, a substance which prevents the lung tissue sticking together. Also with the formation of blood vessels in the lungs, they will now also be developing air sacks. Brain wave activity starts this week for auditory and visual activity.
Week 27: Bumping and thumping is becoming stronger as your baby grows stronger, you should be feeling around 10 kicks in a two hour period. Baby’s lungs are growing rapidly and there is continual development with brain patterns.
Week 28: This is when the eyelids un-fuse and open up. Muscle tone is improving, and the lungs are capable of breathing air. The chances of a baby being born premature from now on, has a greatly improved chance of surviving.
Week 29: Eye lashes have now grown, and although still unable to focus, baby’s eyes are now sensitive to dark and light. At this stage of pregnancy the senses of sound, smell and taste are developing. By the end of the week your baby will be able to move its eyes in their sockets.
Week 30: Baby is now storing up nutrients taken in by you. Calcium for skeletal development, protein for growth and iron for blood cells. By the end of the week the languno (the small hairs that covered the baby’s body), is nearly all gone apart from some patches on the shoulders and back.
Week 31: As the actual growth starts to slow down, the internal organs are still maturing, so make sure your still getting enough folic acid, iron and calcium. Should your baby be born this week they would have the ability to breath, see, listen learn and remember.
Week 32: The baby’s iris is now reacting to light. All five senses are now registering with your baby, although smell is limited as baby can’t breathe air in the uterus.
Week 33: your baby may now be sucking its fingers. Constipation could be starting for you as your uterus puts more and more pressure on your bowels.
Week 34: The pigment of the eyes is not quite fully developed yet, this leaves the eyes looking blue regardless of final colour. And this week your baby will start to develop its own immune system.
Week 35: In baby boys the decent of the testes will complete any time now. Your baby may now shift into your pelvis in a head down position, but not all babies’ do this before birth.
Week 36: Dimples on the elbows and knees will be forming as well as creases in the neck area due to continual deposits of fat. Also this fat will help baby maintain its body temperature.
Week 37: Around 85% are born within two weeks of their actual due date (either before or after), so as you enter this stage be aware for signs of labour. The baby is practising being more aware of its surroundings; this is the ‘orientating response’. This is where the baby will turn towards any source of light. The end of this week marks the end of development, growth will now slow down.
Week 38: Meconium is accumulating in the intestines. Meconium is a dark green mass of waste product and cells from the gall bladder, liver and pancreas. Although shortly after birth this will all come out.
Week 39: as the baby is settling into your pelvis, you maybe feeling clumsy and off balance. This is because your centre of gravity shifts. Make sure you’re prepared for your trip to the hospital.
Week 40: welcome to the final week, that’s if you have not given birth already. Your body will be giving the baby antibodies so it can protect its self from many diseases. The baby will finish dropping into its resting place before birth. So congratulations and welcome to your new born child.
