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Hey Viagra users! Do you know how your magic pill works on you? Hmmm…forgotten right! Or are you ignorant about its mechanism? Whatever, am sure about one thing you were startled after reading the title of this write-up! To understand Viagra mechanism we need to first understand how one gets a penis erection. Penile erection process is initiated with sexual excitement. The stimulation generates electrical impulses in the brain and sends it to the nerves going to the penile section. The nerve then releases nitric oxide to increase the production of cyclic GMP in muscle cells of corpus cavernosum simultaneously. Nitric oxide smoothes the muscles and increases the size of the blood vessels allowing high-speed blood flow to the penis. As a result the penis is engorged with blood making it firm and strong for penetrative sex. So what we understand from this is that the level of NO (Nitric oxide) is mainly responsible for giving a strong penile erection. Viagra does not have any direct relaxant effect on the penile section but it enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5). When sexual stimulation leads to the release of Nitric oxide, the inhibition of PDE5 by Viagra causes increased levels of cyclic guanosine monophosphate which gives muscle relaxation and blood inflow to the corpus cavernosum which ultimately helps in getting the required erections of the penis. Now, I am sure you will be able to relate the Nobel Prize winner Dr. Furchgott with Viagra and its functioning. Nitric oxide was initially known as Endothelial Derived Relaxing Factor (EDRF), ERDF was released, when patients took the nitrate-type blood pressure medicines popular in the 1970s and 1980s, and in turn it caused relaxation of the smooth muscles around the blood vessels and the arteries became larger, allowing better blood flow and a lower blood pressure. In 1986, Dr. Furchgott identified the EDRF as nitric oxide. This is where the Viagra makers got the idea of a magic pill for sex which revolutionized the whole idea of impotence. They noticed from the research that the nitrate drugs had certain side-effects on the blood vessels and the arteries; relaxing the smooth muscles around the blood vessels thereby increasing the blood flows in the human body. They related it to the erectile anatomy and discovered Sildenafil citrate, a chemical that inhibited PDE5 inhibitors which is responsible for the level of NO (nitric oxide) in the penile section. Sildenafil Citrate, under the brand name of Viagra, became the pioneer pill for the treatment of erectile dysfunction and received FDA approval on March 27, 1998, the rest is history! After all a better blood flow is the key factor behind a strong erection. So the master mind behind Viagra, in a way, remains Dr. Furchgott, the inventor of nitric oxide. Without the knowledge of the existence of nitric oxide, no one could think of inhibiting phosphodiesterase type 5 to maintain the level of NO to get penis erection. Let’s toast for the good health of Dr. Furchgott and congratulate him on winning the Nobel Prize. Without his discoveries Viagra would not have been possible and millions of men with erectile dysfunction would have continued to live hopelessly and helplessly as ‘ashamed impotents’. Thanks Dr. Furchgott for everything you have given us through your discovery! vimax does penis enlargement work penis enlagement tip penile enlargement stretcher penile enlargement operation truth about penis enargement cheap pennis enlargement vig rx results vimax compare penis enlargement pills

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Male sexual dysfunction is one of the most common health problems affecting men and is more common with increasing age. Chronic ED affects about 5% of men in their 40s and 15-25% of men by the age of 65. Transient ED and inadequate erection affect as many as 50% of men between the ages of 40 and 70. In around 95% of the cases, a suitable treatment can be found. Erectile dysfunction is treatable at any age, and awareness of this fact has been growing. More men have been seeking help and returning to normal sexual activity because of improved, successful treatments for erectile dysfunction. Viagra, Levitra and Cialis Currently, there are three oral medications approved by the Food and Drug Administration (FDA) for the treatment of erectile dysfunction: sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). All these agents block the enzyme phosphodiesterase type 5 (PDE-5) and belong to a class of drugs called phosphodiesterase (PDE) inhibitors. Viagra was the first and is probably the most famous of the three PDE-5 inhibitors used to treat erectile dysfunction. Viagra was approved as an effective agent for treating erectile dysfunction in March 27, 1998. Viagra is manufactured by Pfizer, Inc. Levitra was the second PDE-5 inhibitor to come to market in the United States, and it was approved by the FDA in August 19, 2003. Levitra is manufactured by Bayer Pharmaceuticals Corporation. Cialis was the third PDE-5 inhibitor to come to market and was approved by the FDA at the end of November 21, 2003. Cialis is manufactured by Lilly ICOS LLC. The major advantage of PDE-5 inhibitors is that they do not cause an erection at inappropriate times, because they act only in response to sexual stimulation. If there is no sexual stimulation drug remains in the background. All three are taken orally prior to planned sexual activity, acting to increase blood flow in the penis in response to sexual stimulation. However, there are important differences between the three, differences that could influence safety, specificity, duration of action, adverse effects, and ultimately, public acceptance within this class of drug. Mechanism of Action PDE-5 inhibitors do not directly cause an erection of the penis, but they alter the body's response to sexual stimulation by enhancing the effect of the nitric oxide, a chemical that is normally released during stimulation. Nitric oxide causes relaxation of the muscles in the penis, which allows for better blood flow to the penile area. Effectiveness of PDE-5 Inhibitors All 3 PDE-5 inhibitors have demonstrated excellent efficacy. Viagra, at 84%, is slightly more effective than Cialis at 81% and Levitra at 80%. Pharmaceutical Forms, Onset of Action and Duration of Effect Viagra and Levitra differ only minimally in terms of their structure, while Cialis differs markedly from Viagra and Levitra in terms of its molecular structure, which is also reflected in pharmacokinetic differences. Viagra: 25 mg, 50 mg 100 mg tablets Onset of action: 30 minutes (effect delayed if taken with food) Duration of action: 4 to 5 hours Levitra: 2.5 mg, 5 mg, 10 mg, 20 mg tablets Onset of action: 25 minutes (effect delayed by fatty meal) Duration of action: 4 to 5 hours Cialis: 5 mg, 10 mg, 20 mg tablets Onset of action: 16-45 minutes (effect NOT delayed by food) Duration of action: 36 hours All three drugs require sexual stimulation to be effective. Viagra should be taken on an empty stomach it works better if you do not eat a high-fat meal around the time you take it. Levitra may be slightly less effective if you eat a high-fat meal, but a moderate-fat meal does not reduce its effectiveness. Cialis works without regard to what you eat. Viagra and Levitra have similar half-lives, and onset and duration of action. Cialis has a slower onset of action and longer duration of action, which is attributed to its longer half-life. Patients who wish for spontaneity may opt for Cialis, which may allow for successful intercourse up to 36 hours postdose, even though it takes longer to reach peak effect. The considerably longer duration of effect for Cialis will likely allow less frequent dosing and greater impulsiveness between partners, but also could potentially prolong adverse effects. Dosage The recommended dose for Viagra is 50 mg, and the physician may adjust this dose to 100 mg or 25 mg, depending on the patient. The recommended dose for either Levitra or Cialis is 10 mg, and the physician may adjust this dose to 20 mg if 10 mg is insufficient. A lower dose of 5 mg is available for patients who take other medicines or have conditions that may decrease the body's ability to use the drug. Levitra is also available in a 2.5 mg dose. None of these PDE-5 inhibitors should be used more than once a day. Possible Side Effects Although all three drugs are generally well tolerated, side effects are still possible. Most common side effects: Viagra: facial flushing, headache, indigestion Levitra: facial flushing, headache Cialis: headache, indigestion Less Common Side Effects: Viagra: altered vision, dizziness, nasal, congestion Levitra: indigestion, nausea, dizziness, nasal congestion Cialis: back pain, muscle aches, nasal congestion, facial flushing, dizziness Precautions and Contraindications All PDE-5 inhibitors are absolutely contraindicated in persons who take organic nitrates. Alpha-blockers Viagra has precautionary labeling advising against taking 50 mg or 100 mg doses within four hours of taking a alpha-blocker. The 25 mg dose of Viagra has not been shown to significantly decrease blood pressure and in patients who take 25 mg of Viagra, use of any of the alpha-blockers is considered safe. Levitra is contraindicated in patients taking alpha-blockers. Cialis is contraindicated in patients taking alpha-blockers, except for tamsulosin (Flomax). Since both Viagra and Levitra have moderate vasodilatory and hypotensive effects, they should not be given in the presence of marked arterial or orthostatic hypotension, and should only be administered with caution in aortic stenosis or hypertrophic obstructive cardiomyopathy. Men who have had a heart attack or stroke within the past 6 months and those with certain medical conditions (e.g., uncontrolled high blood pressure, severe low blood pressure or liver disease, unstable angina) that make sexual activity inadvisable should not take Cialis. Dosages of the drug should be limited in patients with kidney or liver disorders. Conclusions The differences between the 3 drugs are not great. All appear to be effective and safe. Levitra has less side effects compared to Viagra and lasts about the same time as Viagra in the body. Cialis has few side effects and lasts longer in the body. This allows increased spontaneity and less frequent dosing than either Levitra or Viagra. However, the longer half-life of Cialis imposes increased risk for drug interactions. pnis enlargement testimonials penile enlargement without pills pnis enlargement pills review penis enargement program surgical penis enlarement homemade penis elargement elargement forum free matter penis size vimax penis enlargement doctor penis enhancement photo

Today we are going to discuss one of my pet peeves, and learn about email etiquette. Those who don't BCC send, an email nightmare. When you send your friends an email showing all email in the to: or CC line and those people forward that email to their address book of friends, suddenly 500 people now have your friends email addresses. These email addresses remain in the email, because most people don't do their part to edit them out. So when you forward an email that has 200 emails in the two field and your friend forwards it on to 300 of their friends. You now have an email with 500 emails. Today I received just that email and I was able to harvest 500 email addresses from that one email that was carelessly sent by a friend of mine. So now 500 people I didn't know had my email address. Ever wonder why you receive so much spam, adds to enlarge your penis or adds saying you have been approved for a mortgage? This is one reason. I do not believe for one moment that you would hand out your friends home address or phone number to people that you don’t know? The same consideration should really be taken into thought when sending out email. You have the resources right there at your finger tip to protect your friends and family from spammers, stalkers, etc. So please use the BCC, instead of To or CC when sending group e-mails. Don't ever give out another person's e-mail address without their permission. Like I said above an email address should be treated just as a phone number or home address is treated. So how does on BCC send. I have collected a few resources to help you. How to BCC send in Yahoo http://help.yahoo.com/help/us/mail/send/send-01.html How to BCC send in hotmail Example: If you were to enter these email addresses: 'To:' xxxxxx@todays-woman.net 'CC:' 'BCC:'xxx@hotmail.com, xx@aol.com, xxxx@yahoo.com Each recipient will receive a copy of your email but it would look like this From: "Your Name here". To: xxxxxx@todays-woman.net Cc: How to BCC send in Aol http://help.channels.aol.com/article.adp?catId=1&sCId=105&sSCId=1051&articleId=217065 How to BCC send in outlook http://support.microsoft.com/default.aspx?scid=kb;en-us;299804 How to BCC in Netscape http://wp.netscape.com/browsers/using/messenger/autobcc.html How to BCC in juno http://www.juno.com/contact/brand.html?next=http://www.juno.com/support/40/misc-bcc.html How to BCC in MSN Explorer To add Bcc: recipients to a message in MSN Explorer: • Click on More on the Write E-mail screen. • Select Show Bcc: Then use the Bcc: field like the To: field. I hope this article was of some help. Now please do your part in helping spam stay out of my inbox, as well as your friends and family inbox by BCC sending. penis enlagement system penile enlargement procedure enlargment manhattan penile penis enhancement patch pnis enlargement picture free penis enlarement exercise do penis enhancement pills really work penis enlagement information penis enhancement photo

The term heart disease is a very broad term. Problems can arise within the heart muscle, arteries supplying blood to the heart muscle, or the valves within the heart that pump blood in the correct direction. Understanding the differences between each disease of the heart can help with the confusing applications of the term heart disease. Coronary artery disease or CAD is the most common type of heart disease and the leading cause of death in both genders in the U.S. Coronary artery disease affects the arteries supplying blood to the heart muscle. These coronary arteries harden and narrow due to the buildup of a waxy cholesterol, fatty substance referred to as plaque. This plaque buildup is known as atherosclerosis. The increase in plaque buildup causes the coronary arteries to become narrower. This will cause blood flow to become restricted, decreasing the amount of oxygen delivered to the heart muscle. Decreasing the amount of oxygen supplied to the heart muscle can cause angina (chest pain) and lead to a heart attack. Coronary artery disease over time can weaken the heart muscle contributing to heart failure and arrhythmias (abnormal heart rhythms). Coronary heart disease is another confusing type of heart disease. Coronary heart disease is not the same thing as coronary artery disease. While coronary artery disease refers to the coronary arteries, coronary heart disease refers to the diseases of the coronary arteries and resulting complications. This includes such complications such as chest pain, a heart attack, and the scar tissue caused by the heart attack. Understanding this subtle difference between the two may impress your cardiologist. Cardiomyopathy is a disease affecting the muscle of the heart. Cardiomyopathy can be genetic or caused by a viral infection. Cardiomyopathy can be classified as primary or secondary. Primary cardiomyopathy is attributed to a specific cause (hypertension, congenital heart defects, heart valve disease). Secondary cardiomyopathy is attributed to specific causes (diseases affecting other organs). There are three main types of cardiomyopathy. Dilated cardiomyopathy is enlargement and stretching of the cardiac muscle. Hypertrophic cardiomyopathy causes thickening of the heart muscle. Restrictive cardiomyopathy causes the ventricles of the heart to become excessively rigid causing blood flow to the ventricles to be difficult between heartbeats. Valvular heart disease is a disease that affects the valves of the heart. Valves within the heart keep the blood flowing in the correct direction. Damage to valves can be caused by a variety of conditions leading to regurgitation or insufficiency (leaking valve), prolapse (improper closing of the valve), or stenosis (narrowing of the valve). Valvular heart disease can be genetic. Valvular heart disease can also be caused by certain infections such as rheumatic fever, and certain medications or radiation treatments for cancer. The pericardium is a sac that encompasses the heart. Pericardial disease is inflammation (pericarditis), stiffness (constrictive pericarditis), or fluid accumulation (pericardial effusion) of the pericardium. Pericardial disease can be caused by many things such as occurring after a heart attack. Congenital heart disease is a form of heart disease that develops before birth. Congenital heart disease is an extremely broad term. However, these diseases usually affect the formation of the heart muscle, chambers, or valves. A few examples include coarctation or a narrowing of a section of the aorta; atrial or ventricular septal defect is referred to as holes in the heart. Congenital heart disease should be classified more accurately as an inborn defect that occurs in around 1% of births. Congenital heart disease may be inherited (heredity), or caused by certain infections such as German measles contracted while pregnant. However, researchers are currently studying factors that may cause congenital heart disease. Heart failure is another type of heart disease characterized by the heart’s inability to effectively pump enough blood to the body’s organs and tissues. When the body’s vital organs do not receive enough blood flow certain signs and symptoms can occur such as shortness of breath, fatigue, and fluid retention. Congestive heart failure is a type of heart failure that leads to fluid buildup in the body. It is important to note that not all heart failure is congestive. Heart failure may result from other cardiovascular diseases such as cardiomyopathy or coronary heart disease. Heart failure may come on suddenly or develop over many years. The month of February is the National Heart Disease awareness month. However, heart disease awareness should be each and every day. With staggering statistics, awareness begins with understanding the different types of heart disease. A diet and lifestyle that is conducive to heart health can mean the difference between life and being a statistic. Copyright 2006 Kristy Haugen pnis girth enlargement penis enargement video does vig rx work vimax extender vimax penis pill cheapest pnis enlargement pills penile enlargement without pills cheap penile enlargement penis enhancement photo

Bladder infections can make life very uncomfortable for those who have them. However, there is a lot you can do at home to make these infections less unpleasant, and get rid of them quickly. The best home remedy is to drink a lot of fluids. This is probably the single most important remedy for immediate relief and comfort. By urinating, you will flush out the bacteria from your blood faster. The longer any amount of urine stays in the bladder, the more bacteria stay in there. It is believed that E coli doubles its population about every 20 minutes. And more bacteria means more discomfort. Taking a hot bath is the next best thing that you can do. Many women vouch for a hot bath to get immediate relief from pain and inflammation caused by bladder infection. Taking anti-inflammatory medicines like aspirin or ibuprofen also provides relief to a lot of people. They reduce the inflammation in the bladder and thereby lessen the burning. About 1,000 mg of vitamin c consumed every day will acidify the urine enough to stop further bacterial growth. This is an especially good idea if you're having problems with recurring bladder infections or if you do not have access to quick medical help. But you must keep in mind that some antibiotics prescribed for bladder infections do not work in acidic urine. It is advisable to inform your doctor if you're taking vitamin C along with the dosage amounts. Cranberry juice is known to help for the same reasons mentioned above. Wiping from front to back after going to the bathroom helps prevent infections from occurring. It helps to move bacteria away from, not toward, the vagina and the opening of the urethra. Going to the bathroom before intercourse helps flush out bacteria that may be present in the vagina and otherwise might get pushed into the bladder by intercourse. You must also visit the bathroom after intercourse. A man's penis can massage bacteria present in the opening of the urethra into the bladder, and a rinse will help you clean yourself. Bladder infections can be prevented if you use pads instead of tampons for the same reasons mentioned above. Lastly, good hygiene always helps to keep bladder infections away. This means wearing cotton underwear that keeps you dry, avoiding tight jeans that decrease ventilation, and most of all, keeping clean.